pcFluor2 switches reversibly more than 1,000 times in living HeLa cells while keeping over 90% of its brightness.
Map debates and measure what claims hold up.
Open a paper or a question, and researchers attack or support it one claim at a time. Every change is kept as a version, and each claim gets an argument strength between 0 and 1 that shows whether it is still standing.
For researchers, reviewers and editors. Reading will be free and need no account.
“pcFluor2 switches reversibly more than 1,000 times in living HeLa cells while keeping over 90% of its brightness.”
In Figure 3, fluorescence after 1,000 off/on cycles stays at 92% of the first cycle (n = 24 cells).
“pcFluor2 switches reversibly more than 1,000 times in living HeLa cells while keeping over 90% of its brightness.”
The cells in Figure 3 were imaged at 21 °C; at 37 °C related proteins lose brightness much faster per cycle.
How a debate works
Claims answer claims
A paper is split into claims. Anyone can add a claim that attacks or supports another one.
AttacksSupports
Every change is a version
Each contribution creates a new version of the debate, and nothing is ever deleted. You hold the version you stand behind.
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Your judgment is scored, not bet
When you hold a version you say how well you expect its claims to hold up. Two weeks later the debate answers and your judgment moves up or down. Nobody else wins or loses.
Strength0.56
What you will be able to do
Researchers
Discuss a draft privately with peers you invite. When it is ready, publish the discussion on your paper, preprint or open question, answer objections claim by claim, and show editors where the debate stands.
Reviewers
Write a structured review in three questions (conclusion, results, methods) and be paid from the discussion's review bounty. Your record shows how your judgments held up.
Editors
Read a report of the strongest claims across every line of argument and the open objections, then accept a specific version of the debate for publication.
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